MOTS-C

What is MOTS-c?

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. It carries CAS number 1627580-64-6, molecular formula C101H152N28O22S2 and a molecular weight of 2174.6 g/mol. Kovalabs supplies it as a lyophilised research material.

The peptide sequence is Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg, and it is catalogued in PubChem under CID 146675088. It is a reference compound for non-clinical laboratory work, not a consumer product and not a medicine.

Is MOTS-c legal in the UK?

MOTS-c is not a controlled drug under the Misuse of Drugs Act 1971 and it is not a scheduled substance. It is supplied strictly as a research chemical for laboratory use only. It is not authorised as a medicine in the UK, cannot be sold or bought for human or veterinary consumption, and the purchaser is responsible for handling, storage and compliance with the conditions set out in our research disclaimer.

How is identity and quality assured?

Each batch of MOTS-c is released after independent analytical testing. Purity is assessed at 99% or greater by HPLC, and identity is confirmed against the expected mass for C101H152N28O22S2 (2174.6 g/mol). The verified identifiers (CAS 1627580-64-6, PubChem CID 146675088) let researchers cross-check the material against public databases.

A certificate of analysis accompanies every batch. You can review documentation on the CoA page to confirm the lot you receive matches the stated identity and purity before any research use.

What does the research on MOTS-c investigate?

The published literature studies MOTS-c as a signalling peptide in the mitochondrial and AMPK research pathway, using in-vitro and animal model systems. These are pre-clinical observations only: none of this establishes a benefit, effect or outcome in humans, and MOTS-c is not a licensed medicine.

For the mechanistic background and the cited studies, see the research monograph at MOTS-c: a mitochondrial-derived peptide in research. That article handles the evidence in depth; this product page covers identity, legality, quality and supply.

Synthesis and supply

MOTS-c is manufactured to research grade and shipped as a white to off-white lyophilised powder. For bench work it is reconstituted in a suitable solvent such as bacteriostatic water; store the lyophilised solid at -20C, dry and protected from light, and hold reconstituted material at 2-8C.

MOTS-c sits in the metabolic research category alongside other mitochondrial and metabolic-pathway reference compounds. Related research materials in the catalogue include retatrutide and cagrilintide. All are supplied for laboratory research use only, not for human or veterinary use.